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Human Genetics

PHARMACOGENETICS

RDB2070 Cytochrome Cyp2C19

The cytochrome P450 (CYP) family of heme monooxygenases comprise the most important group of phase 1 detoxication enzymes of the liver.

These enzymes oxidate a wide range of endogenous as well as exogenous compounds using atmospheric oxygen. The cytochrome P450 gene family contains 60 to 100 different genes, of which only a small group is involved in drug and chemical transformations.

Currently there are eleven different alleles of the CYP2C19 gene described, of which nine code for inactive versions of the enzyme. Individuals can be characterized as extensive (EMs) metabolizers if at least one wildtype allele is present or poor metabolizers (PMs) if both alleles code for inactive enzymes connected with effects on for example drug levels.

AID CYP2C19 Kit enables detection of most important CYP2C19 alleles.

 

 

Characteristics

  • Characterization of CYP2C19 alleles
  • Differentiation between homozygous and heterozygous genotype
  • PCR with subsequent lineprobe assay
  • Specimen: human DNA isolated from buccal swab, Citrate- or EDTA-blood or biopsy
  • Control bands on every strip show correct DNA isolation, amplification and hybridization
  • Results within 4 hours
  • Suited for automated systems
  • Evaluation and documentation with AID Scanning system

 

Reader Systems

AID Scanner