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Human Genetics

PHARMACOGENETICS

RDB2205 N-Acetyltransferase 2

N-Acetyltransferase 2 (NAT2) is a enzyme of liver tissue, involved in metabolism of Xenobiotics. Substrates of NAT2 are drugs like Isoniazid, Hydralazine or Sulfasalazine.

There exist several polymorphisms of NAT2 gen, most of them are linked with reduced enzyme activity. Dependent on combination of wild type and polymorphisms individuals can show the phenotype slow, intermediate or rapid acetylator. About 60% of Caucasians have slow acetylator phenotype.

NAT2 phenotype has direct influence on drug level of pharmaceuticals, which are metabolized by NAT2. Determination of NAT2 phenotype is crucial for accurate therapy with corresponding drugs.

AID NAT2 Kit enables determination of the most frequent polymorphisms of the NAT2 gene.

 

 

Characteristics

  • Characterization of the most frequent polymorphisms of the NAT2 gene
  • Differentiation between homozygous and heterozygous genotype
  • PCR with subsequent lineprobe assay
  • Specimen: human DNA isolated from buccal swab, Citrate- or EDTA-blood or biopsy
  • Control bands on every strip show correct DNA isolation, amplification and hybridization
  • Results within 4 hours
  • Suited for automated systems
  • Evaluation and documentation with AID Scanning system

 

Reader Systems

AID Scanner