deutsch deutschenglish english

Infections Diseases

ANTIBIOTIC RESISTENCES

RDB2184 TB Fluoroquinolone, Ethambutol

The incidence of multidrug resistant and extremely drug resistant strains of Mycobacterium tuberculosis is a serious threat to worldwide TB control. Multidrug-resistant tuberculosis (MDR-TB) is caused by strains resistant to at least Isoniazid (INH) and Rifampin (RIF), the two most powerful first-line Anti-TB drugs.

Strains, which cause extensively drug-resistant TB (XDR-TB), are not only resistant to INH and RIF but also to at least any Fluoroquinolone (FQ) and one of the second-line injectable drugs Amikacin, Kanamycin and Capreomycin.

Resistant TB is more difficult to treat than drug-susceptible TB, there are stronger adverse effects, therapy is more expensive and the patient is more likely to stay infectious for a longer period of time.

Rapid tests that detect resistances are necessary for early initiation of effective therapy. Culture tests can take several weeks.

Characteristics

  • Detection of Mycobacteria of the Mycobacterium tuberculosis complex and its resistances to Fluoroquinolone und Ethambutol
  • For culture and clinical specimens
  • High sensitivity and specificity for resistances to first line drugs
  • Modular system of the test:
    Module 1: INH/RIF
    Module 2: Aminoglycoside
    Module 3: FQ/EMB
  • Results within 4 hours
  • Suited for automates systems
  • Control bands on every strip shows correct DNA isolation, amplification and hybridization
  • Evaluation and documentation with AID scanner and software

 

Reader Systems

AID Scanner