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Infectious Diseases

ANTIBIOTIC RESISTANCES

RDB2180 ESBL

Increasing prevalence of resistance against cephalosporins in extended-spectrum ß-lactamase (ESBL)-producing Enterobacteriaceae has continuously been reported over the past years.

Depending on the ESBL type, these b-lactamases have the ability to hydrolyse various penicillins, first-, second- and third-generation cephalosporins, and aztreonam (but not cephamycins or carbapenems). Currently, the most prevalent ESBLs include TEM, SHV and CTX-M enzyme types.

Phenotypic susceptibility testing for ESBLs may be complicated by the presence of multiple ß-lactamases in a single bacterial strain, e.g. ESBLs, AmpCs and carbapenemases, and by different levels of b-lactamase gene expression.Genotypic tests have the potential to accurately identify different ß-lactamase genes
and mutations that result in ESBLs

Characteristics

  • Developed for rapid detection of ESBL-genes within 5 hours
  • Detection of the most important mutations in TEM and SHV as soon as CTX-M and the Klebsiella pneumoniae Carbapenemase (KPC)
  • For culture and clinical specimens
  • Results within 4 hours
  • Suited for automated systems
  • Control bands on every strip shows correct DNA isolation, amplification and hybridization
  • Evaluation and documentation with AID scanner and software

 

Reader Systems

AID Scanner