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Human Genetics

IMMUNOLOGY

RDB2015 HLA-B*27

It has been known for a long time that there is a close connection between the HLA-B*27 allele and ankylosing spondylitis (SPA; synonym: Bechterew’s disease). About 90-95% of all patients suffering from SPA are HLA-B*27 positive, with a phenotypic frequency of approx. 7-9% in Caucasians.

Owing to this high association with the disease, the typifying of HLA-B*27 is suitable for the differential diagnosis of Spondylitis ankylosans. The other seronegative spondylarthritides are also associated to a high percentage with HLA-B*27.

AID HLA-B*27 Kit enables the detection of risk allele for ankylosing spondylitis.

 

 

Characteristics

  • Differentiation between homozygous and heterozygous AS-risk allele HLA-B*27
  • PCR with subsequent lineprobe assay
  • Specimen: human DNA isolated from buccal swab, Citrate- or EDTA-blood or biopsy
  • Also suited for ‚DirektPCR‘ from blood
  • Control bands on every strip show correct DNA isolation, amplification and hybridization
  • Results within 4 hours
  • Suited for automated systems
  • Evaluation and documentation with AID Scanning system

 

Reader Systems

AID Scanner