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PCR detection of celiac disease risk alleles

AID celiac disease PCR kit – detection of HLA-DQ risk alleles for celaic disease

Accurate detection of celiac disease risk alleles

Detection of DQ2 and DQ8 HLA heterodimers may serve as a diagnostic marker for celiac disease as HLA-B*27 does for ankylosing spondylitis.

In individuals with gastrointestinal malfunction, the presence of DQ2 and/or DQ8 would increase the chance that the person has celiac disease whereas the absence of this molecule would greatly argue against this assumption.

In a recent European report, only 0.5% of celiac patients lacked both DQ2 and DQ8. As little as 0.3% of tissue transglutaminase autoantibody-positive individuals do not have DQ2 or DQ8. The majority of DQ2- and DQ8-negative celiac disease patients did in fact carry one half of the DQ2 heterodimer, often in the form DR7 (DQB1*0201)

The AID Celiac Disease Kit enables the detection of genes for predisposition heterodimers HLA-DQ(α1*0501, β1*0201) and HLA-DQ(α1*03, β1*0302) as well as DR4 allele.




  • Accurate detection of celiac disease risk alleles
  • Diagnostic is independent from a IgA antibody deficiency
  • Detects patients with latent or potential celiac disease
  • Differentiation between homozygous and heterozygous genotype
  • PCR with subsequent lineprobe assay
  • Specimen: human DNA isolated from buccal swab, Citrate- or EDTA-blood or biopsy
  • Control bands on every strip show correct DNA isolation, amplification and hybridization
  • Results within 4 hours
  • Suited for automated systems
  • Evaluation and documentation with AID Scanning system
  • RDB 2105


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