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Human Genetics

PHARMACOGENETICS

RDB2090 Glutathione-S-Transferase

Glutathione-S-transferases (GST) are a multigene family of enzymes involved in detoxification and, sometimes, activation of a wide variation of exogenous and endogenous substances. The enzymes detoxify carcinogenic polycyclic aromatic hydrocarbons and conjugate isothiocyanates by transducing them in less reactive and more water soluble products

Several polymorphisms of the GST genes are described resulting in enzymes with reduced activity. Depending on GST genotype patients can show different sensitivity against environmental pollutant and are more or less capable in metabolizing for example electrophilic carcinogens.

AID GST Kit enables determination of polymorphisms of Glutathione-S-Transferases (GST)
M1 and T1

 

 

Characteristics

  • Characterization of polymorphism M1 and T1 of GST gene
  • Differentiation between homozygous and heterozygous genotype
  • PCR with subsequent lineprobe assay
  • Specimen: human DNA isolated from buccal swab, Citrate- or EDTA-blood or biopsy
  • Control bands on every strip show correct DNA isolation, amplification and hybridization
  • Results within 4 hours
  • Suited for automated systems
  • Evaluation and documentation with AID Scanning system

 

Reader Systems

AID Scanner