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Human Genetics

PHARMACOGENETICS

RDB2280 Statin-Tolerance

Statins are used to reduce LDL cholesterol level and belong to one of the most often prescribed drugs. Efficacy and tolerance for patients depend on the correct selection of substance and dosage. Because of genetic polymorphisms resorption and metabolism of statins can vary drastically from patient to patient.

The kit detects SNPs in the genes SLCO1B1, ABCG2 and ABCB1, which are coding for transporter proteins. The SNPs are associated with a reduced transportation rate of some statin groups into and out of the liver which bears the risk of overdosing.

For a successful statin therapy it is very helpful to know the genotype of relevant SNPs of the patient in order to avoid adverse effects caused by overdose and reduced efficacy.

The AID Kit Statin-Tolerance enables characterization of most important SNPs  for optimization of a statin therapy.

 

 

 

 

Characteristics

  • Characterization of five SNPs on SLCO1B1, ABCG2 and ABCB1 genes
  • Differentiation between homozygous and heterozygous genotypes
  • PCR with subsequent lineprobe assay
  • Specimen: human DNA isolated from Citrate- or EDTA-blood
  • Control bands on every strip show correct DNA isolation, amplification and hybridization
  • Results within 4 hours
  • Suited for automated systems
  • Evaluation and documentation with AID Scanning system

 

Reader Systems

AID Scanner